Neostigmine bromide
CAS No. 114-80-7
Neostigmine bromide ( —— )
Catalog No. M10524 CAS No. 114-80-7
Neostigmine bromide(Prostigmin) is a reversible acetylcholinesterase inhibitor and a parasympatho-mimetic.
Purity : >98%(HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameNeostigmine bromide
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NoteResearch use only, not for human use.
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Brief DescriptionNeostigmine bromide(Prostigmin) is a reversible acetylcholinesterase inhibitor and a parasympatho-mimetic.
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DescriptionNeostigmine bromide(Prostigmin) is a reversible acetylcholinesterase inhibitor and a parasympatho-mimetic. By interfering with the breakdown of acetylcholine, neostigmine indirectly stimulates both nicotinic and muscarinic receptors. It binds to the anionic site of cholinesterase. The drug blocks the active site of acetylcholinesterase so the enzyme can no longer break down the acetylcholine molecules before they reach the postsynaptic membrane receptors. This allows for the threshold to be reached so a new impulse can be triggered in the next neuron. In myasthenia gravis there are too few acetylcholine receptors so with the acetylcholinesterase blocked, acetylcholine can bind to the few receptors and trigger a muscular contraction.
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Synonyms——
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PathwayEndocrinology/Hormones
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TargetAChR
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RecptorAChE
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Research AreaMetabolic Disease
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Indication——
Chemical Information
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CAS Number114-80-7
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Formula Weight303.20
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Molecular FormulaC12H19BrN2O2
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Purity>98%(HPLC)
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SolubilityWater: 60 mg/mL (197.88 mM)
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SMILES[Br-].CN(C)C(=O)OC1=CC=CC(=C1)[N+](C)(C)C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Trevisani GT, et al. Dis Colon Rectum. 2000 May;43(5):599-603.
molnova catalog
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