Neostigmine bromide

CAS No. 114-80-7

Neostigmine bromide ( —— )

Catalog No. M10524 CAS No. 114-80-7

Neostigmine bromide(Prostigmin) is a reversible acetylcholinesterase inhibitor and a parasympatho-mimetic.

Purity : >98%(HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Neostigmine bromide
  • Note
    Research use only, not for human use.
  • Brief Description
    Neostigmine bromide(Prostigmin) is a reversible acetylcholinesterase inhibitor and a parasympatho-mimetic.
  • Description
    Neostigmine bromide(Prostigmin) is a reversible acetylcholinesterase inhibitor and a parasympatho-mimetic. By interfering with the breakdown of acetylcholine, neostigmine indirectly stimulates both nicotinic and muscarinic receptors. It binds to the anionic site of cholinesterase. The drug blocks the active site of acetylcholinesterase so the enzyme can no longer break down the acetylcholine molecules before they reach the postsynaptic membrane receptors. This allows for the threshold to be reached so a new impulse can be triggered in the next neuron. In myasthenia gravis there are too few acetylcholine receptors so with the acetylcholinesterase blocked, acetylcholine can bind to the few receptors and trigger a muscular contraction.
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    AChR
  • Recptor
    AChE
  • Research Area
    Metabolic Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    114-80-7
  • Formula Weight
    303.20
  • Molecular Formula
    C12H19BrN2O2
  • Purity
    >98%(HPLC)
  • Solubility
    Water: 60 mg/mL (197.88 mM)
  • SMILES
    [Br-].CN(C)C(=O)OC1=CC=CC(=C1)[N+](C)(C)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Trevisani GT, et al. Dis Colon Rectum. 2000 May;43(5):599-603.
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